That is a move from the nearby NASA-owned Kennedy Space Center, where the launch was originally planned in November.
"Everybody involved with the mission is pretty tight-lipped about it", Space.com reported previous year.
But the launch was delayed. The reusable rocket landed about seven minutes after liftoff, SpaceX said.
The launch is SpaceX's first in what is expected to be a busy year.
SpaceX has previously launched a pair of national security-related missions, a spy satellite for the National Reconnaissance Office and the robotic X-37B space plane for the U.S. Air Force. It's aiming for more this year.
CEO Elon Musk says the heavy-lift launcher's debut test flight - carrying his own Tesla Roadster sports auto into space - is possible from KSC before the end of this month.
SpaceX's first mission of 2018 has more than its share of mystery. Zuma will be the first before the company premiers its new Falcon Heavy rocket, sometime later in January. So far, five "flight proven" boosters have flown for a second time. The two-hour launch window opens at 8pm ET.
The 45th Space Wing on Tuesday is scheduled to deliver its year-ahead forecast of local launch activity to the National Space Club Florida Committee.