Kiki Bertens of the Netherlands 6-2, 6-7 (5), 8-6 in the third round on Friday (Saturday NZT). She couldn't do the same this time.
As Keys reflected on the defeat she said it showed just how mentally strong Williams was in coping with the added pressure of being favorite to win virtually every match she plays.
Nadal will be up against the promising Alex de Minaur, who beat Pierre Hugues Herbert 6-2, 6-7 (8), 7-5, 6-3.
Keys was the seventh of the top 10 seeds to lose before the middle Sunday, testimony to the strength of the women's game or confirmation of Johanna Konta's contention after her defeat against Dominika Cibulkova the previous evening that the seedings do not necessarily reflect the quality of the opponent? It is timed for release as the anticipation crests with Roger as returning champion, 10 years after their famed 2008 Wimbledon championship - an epic match so close and so reflective of their competitive balance that, in the end, the true victor was the sport itself.
Tenth seed Keys, who had made at least the quarter-finals of her last three majors, lost in the third round 7-5, 5-7, 6-4 to Russian qualifier Evgeniya Rodina, ranked 120th in the world.
"Honestly, I think today was a massive mishandle of nerves", the 23-year-old told reporters.
In one video, Williams appears to be applying makeup as Alexis plays with her makeup case and grabs different items stuffing them in her mouth. Happy for the victory and happy with way I played.
German fourth seed Alexander Zverev made the third round, seeing off Taylor Fritz of the United States 6-4, 5-7, 6-7 (0/7), 6-1, 6-2 and faces Latvian qualifier Ernests Gulbis for a spot in the last 16.
French Open semi-finalist Keys struggled for most of the match as she committed 48 unforced errors in a disappointing display.