Florence has already killed at least 35 people, including 26 in North Carolina and eight in SC where local media reported that two mental health patients drowned on Tuesday when the sheriff's van the women were in crashed.
At least 37 people, including several young children, have died from Florence, which brought unprecedented rainfall and flooding to the Carolinas.
Thousands of people are still in shelters in North Carolina anxiously waiting to find out if they have a home to go back to.
Officials across the state are cautioning residents that more floods are expected this week.
Roads remain treacherous, he said, and some are still being closed for the first time as rivers swelled by torrential rains inland drain toward the Atlantic.
Kinston Police in North Carolina also posted a video on Facebook showing clumps of fire ants in flood waters, warning residents to stay safe.
Waze told USA Today it was working with local governments and volunteer map editors to mark road closures in North Carolina, South Carolina and Virginia. Almost 50,000 homes and businesses remain without power in the county where Wilmington is located.
Human and animal waste is mixing with the swirling floodwaters, which have killed about 3.4 million chickens and 5,500 hogs on farms.
At Fayetteville, about 100 miles (160 kilometers) inland, near the Army's sprawling Fort Bragg, flooding from Cape Fear River got so bad that authorities closed a vehicle bridge after the water began touching girders supporting the span's top deck. "I don't really know what we're gonna do", one resident tells Meminger.
"People need to understand this will not be a week-long process", Jordan said.
The Transportation Department advised northbound motorists to take a wide detour around the area by using I-85 from Georgia through South Carolina's Upstate and on to Charlotte.